With 3D printers like the Open-5x or tool changers (e.g. Prusa XL) both, 5-axis simultaneous 3D-printing as well as hybrid manufacturing (additive followed up by subtractive), is more accessible than they ever were.

For those already venturing into this endeavor: What is your toolchain/software?

Currently, I finish the additive/3D print before running a second gcode for the subtractive part (contact surfaces, threads, …). This is far from an efficient and powerful process.