Mine is petty, but is due to having an internal voice when I read. When commonly used words are misspelled, like using loose instead of lose, I ‘hear’ it pronounced as spelled and it drives me nuts. Homophones like their and there don’t annoy me nearly as much.

I also mispronounce words learned from reading that don’t follow normal phonetic patterns that I’m used to, like melee, so I do understand why people mix up loose and lose. It is still painful to read.